Genelia D'Souza, often referred to as the "bubbly girl" in the media, has established herself as a prominent actress in Indian cinema, particularly in the South Indian film industry during the 2000s. With a career spanning across Telugu, Hindi, Tamil, and Marathi languages, she has been a part of over 40 movies. Her journey began with a Parker Pen commercial, which caught the eye of Tamil director S. Shankar, leading to her debut in the Tamil film "Boys" in 2003. Simultaneously, she signed "Tujhe Meri Kasam" (Hindi) and "Satyam" (Telugu), marking the start of her professional film career.

D'Souza holds a Limca World Record for delivering four commercially successful films in four different languages within a single calendar year: "Ready" (Telugu), "Satya in Love" (Kannada), "Santosh Subramaniam" (Tamil), and "Jaane Tu... Ya Jaane Na" (Hindi). Throughout her career, she has received praises for her performances in romantic comedies like "Santosh Subramaniam" and "Jaane Tu... Ya Jaane Na". Some of her commercially successful films include "Satyam" (2003), "Masti" (2004), "Sye" (2004), "Sachein" (2005), "Happy" (2006), "Dhee" (2007), "Ready" (2008), "Katha" (2009), "Urumi" (2011), "Force" (2011), "Velayudham" (2011) and "Tere Naal Love Ho Gaya" (2012). Her performances in "Bommarillu" and "Katha" also earned her two Nandi Special Jury Awards.

Here's a closer look at some of Genelia D'Souza's commercially successful movies:

• Masti (2004): This comedy film revolves around three friends who seek excitement outside their married lives. Genelia plays a crucial role as a woman caught in the chaos caused by her husband's actions. The film's success led to two sequels, "Grand Masti" (2013) and "Great Grand Masti" (2016). The movie grossed ₹20.26 crore at the Indian box office.
• Jaane Tu... Ya Jaane Na (2008): This romantic comedy follows the story of two best friends, Jai and Aditi, who are mistaken for a couple but deny any romantic feelings. The film explores their journey of friendship, love, and self-discovery. "Jaane Tu... Ya Jaane Na" was a major commercial success. It earned ₹55.36 crore at the box office.
• Force (2011): This action thriller features Genelia alongside John Abraham. "Force" was Genelia's third highest-grossing movie, earning ₹27.16 crore at the Indian box office.
• Tere Naal Love Ho Gaya (2012): In this romantic comedy, Genelia reunites with Riteish Deshmukh. She plays Mini, who runs away from home to avoid a forced marriage. She plans a fake kidnapping with Viren, an ex-employee of her father, which leads to them falling in love. NDTV praised D'Souza for her energetic performance, and the film became a box office success. The movie earned ₹19.9 crore.
• Velayudham (2011): Genelia played a journalist in this Tamil film alongside Vijay. CNN-IBN noted that she had a substantial role and fit in adequately.
• Sitaare Zameen Par (2025): In this recent film, Genelia starred opposite Aamir Khan. The film has been lauded for its emotional storytelling and strong performances. "Sitaare Zameen Par" has become her highest-grossing film, earning ₹66.65 crore at the Indian box office. The film grossed ₹261 crore worldwide and emerged as the third highest-grossing Hindi film of 2025 and the fourth highest-grossing Indian film of 2025.

After her marriage to Riteish Deshmukh, Genelia took a hiatus from acting. In 2022, she made her Marathi film debut with "Ved," also starring Deshmukh. The film was a commercial success, becoming the second-highest-grossing Marathi movie after "Sairat". Following the success of "Sitaare Zameen Par," Genelia has announced her involvement in a new film project.